Tuesday 12 December 2017

'Milestone' for scientists in battle against breast cancer

According to the BBC, researchers have developed a near-perfect picture of the genetic events that cause breast cancer
According to the BBC, researchers have developed a near-perfect picture of the genetic events that cause breast cancer
Independent.ie Newsdesk

Scientists say they have made a dramatic breakthrough in the battle against breast cancer.

According to the BBC, researchers have developed a near-perfect picture of the genetic events that cause breast cancer. The study, published in 'Nature', has been described as a "milestone" moment that could help unlock new ways of treating and preventing the disease.

The largest study of its kind unpicked practically all the errors that cause healthy breast tissue to go rogue.

Cancer Research UK said the findings were an important stepping-stone to new drugs for treating cancer.

To understand the causes of the disease, scientists have to understand what goes wrong in our DNA that makes healthy tissue turn cancerous.

The international team looked at all three billion letters of people's genetic code in 560 breast cancers. They uncovered 93 sets of genes that, if mutated, can cause tumours. Some have been discovered before, but scientists expect this to be the definitive list.

Prof Mike Stratton, the director of the Sanger Institute in Cambridge which led the study, said it was a "milestone" in cancer research. He told the BBC: "There are about 20,000 genes in the human genome. It turns out, now we have this complete view of breast cancer - there are 93 of those [genes] that if mutated will convert a normal breast cell into a breast cancer cell.

"We hand that list over to the universities, the pharmaceuticals, the biotech companies to start developing new drugs because those mutated genes and their proteins are targets for new therapeutics. There are now many drugs that have been developed over the last 15 years against such targets which we know work."

Prof Stratton expects new drugs will still take a decade and warns: "Cancers are devious beasts and they work out ways of developing resistance to new therapeutics so overall I'm optimistic, but it's a tempered optimism."

Irish Independent

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