Nearly two years into the Covid-19 pandemic, the world is racing to contain a new coronavirus variant potentially more dangerous than the one that has fuelled relentless waves of infection on every continent.
A World Health Organisation (WHO) panel named the variant Omicron and classified it as a highly transmissible virus of concern.
This is the same category that includes the predominant Delta variant, which is still a scourge driving higher cases of sickness and death in Europe and parts of the United States.
"It seems to spread rapidly," US President Joe Biden said of the new variant, only a day after celebrating the resumption of Thanksgiving gatherings for millions of American families and the sense that normal life was coming back at least for the vaccinated.
In announcing new travel restrictions, he told reporters: "I've decided that we're going to be cautious."
Omicron's actual risks are not understood but early evidence suggests an increased risk of reinfection compared with other highly transmissible variants, the WHO said.
That means people who contracted Covid-19 and recovered could be subject to catching it again.
It could take weeks to know if current vaccines are less effective against it.
In response to the variant's discovery in southern Africa, the United States, Canada, Russia and a host of other countries joined the European Union in restricting travel for visitors from southern Africa, where the variant brought on a fresh surge of infections.
The White House said the US will restrict travel from South Africa and seven other countries in the region beginning on Monday.
Mr Biden said that means "no travel" to or from the designated countries except for returning US citizens and permanent residents who test negative.
Medical experts, including the WHO, warned against any overreaction before the variant was better understood.
But a jittery world feared the worst nearly two years after the tenacious virus emerged and triggered a pandemic that has killed more than five million people around the globe.
"We must move quickly and at the earliest possible moment," British Health Secretary Sajid Javid told MPs.
Omicron has now been seen in travellers to Belgium, Hong Kong and Israel as well as in southern Africa.
There was no immediate indication whether the variant causes more severe disease.
The WHO panel drew from the Greek alphabet in naming the variant Omicron, as it has done with earlier, major variants of the virus.
Even though some of the genetic changes appear worrying, it was unclear how much of a public health threat it posed.
Some previous variants, such as the Beta variant, initially concerned scientists but did not spread very far.
The 27-nation European Union suspended air travel from southern Africa, and stocks tumbled in Asia, Europe and the United States.
The variant is already confirmed in Belgium and is believed to be in Germany.
The Dow Jones Industrial Average dropped more than 1,000 points before an afternoon uptick. The S&P 500 index closed down 2.3pc, its worst day since February.
The price of oil plunged about 13pc.
"The last thing we need is to bring in a new variant that will cause even more problems," German health minister Jens Spahn said.
The member nations of the EU have experienced a massive spike in cases recently.
EU Commission president Ursula von der Leyen said flights will have to "be suspended until we have a clear understanding about the danger posed by this new variant, and travellers returning from this region should respect strict quarantine rules".
She warned that "mutations could lead to the emergence and spread of even more concerning variants of the virus that could spread worldwide within a few months".
"It's a suspicious variant," said Frank Vandenbroucke, health minister in Belgium, which became the first European Union country to announce a case of the variant.
"We don't know if it's a very dangerous variant."
Omicron has yet to be detected in the United States, said Dr Anthony Fauci, the US government's top infectious disease expert.
Although it may be more transmissible and resistant to vaccines than other variants, "we don't know that for sure right now", he told CNN.
Speaking to reporters outside a bookshop on Nantucket Island, where he was spending the holiday weekend, Mr Biden said the new variant was "a great concern" that "should make clearer than ever why this pandemic will not end until we have global vaccinations".
He called anew for unvaccinated Americans to get their widely available doses and for governments to waive intellectual property protections for Covid-19 vaccines so they can be more rapidly manufactured around the world.
Israel, one of the world's most vaccinated countries, announced on Friday that it also detected its first case of the new variant in a traveller who returned from Malawi.
The traveller and two other suspected cases were placed in isolation.
Israel said all three were vaccinated, but officials were looking into the travellers' exact vaccination status.
A total of 61 people who arrived in the Netherlands on two flights from South Africa on Friday tested positive for coronavirus and are in isolation.
Further tests are under way on the travellers who arrived at Amsterdam's Schiphol Airport to establish if any of them have the new Omicron variant.
Some experts said the variant's emergence illustrated how rich countries' hoarding of vaccines threatens to prolong the pandemic.
Fewer than 6pc of people in Africa have been fully immunised against Covid-19, and millions of health workers and vulnerable populations have yet to receive a single dose.
Those conditions can speed up spread of the virus, offering more opportunities for it to evolve into a dangerous variant.
"This is one of the consequences of the inequity in vaccine rollouts and why the grabbing of surplus vaccines by richer countries will inevitably rebound on us all at some point," said Michael Head, a senior research fellow in global health at Britain's University of Southampton.
Visit our Covid-19 vaccine dashboard for updates on the roll out of the vaccination program and the rate of Coronavirus cases Ireland
He urged Group of 20 leaders "to go beyond vague promises and actually deliver on their commitments to share doses".
The new variant added to investor anxiety that months of progress containing Covid-19 could be reversed.
"Investors are likely to shoot first and ask questions later until more is known," said Jeffrey Halley, of foreign exchange broker Oanda.
The Africa Centres for Disease Control and Prevention discouraged any travel bans on countries that reported the new variant.
It said past experience shows that such travel bans have "not yielded a meaningful outcome".
Yet much of the world moved quickly to shut down or severely restrict contact with travellers from southern Africa.
The US restrictions will apply to visitors from South Africa, Botswana, Zimbabwe, Namibia, Lesotho, Eswatini, Mozambique, and Malawi.
The White House suggested the restrictions will mirror an earlier pandemic policy that banned entry of any foreigners who had travelled over the previous two weeks in the designated regions.
The UK banned flights from South Africa and five other southern African countries and announced that anyone who had recently arrived from those countries would be asked to take a coronavirus test.
Canada banned the entry of all foreigners who have travelled to southern Africa in the last two weeks.
The Japanese government announced that Japanese nationals travelling from Eswatini, Zimbabwe, Namibia, Botswana, South Africa and Lesotho will have to quarantine at government-dedicated accommodations for 10 days and take three Covid-19 tests during that time.
Japan has not yet opened up to foreign nationals.
Russia announced travel restrictions effective from Sunday.