The coronavirus so far seems to be taking a higher toll on men in Ireland than on women - mirroring a gender gap also seen in countries like Italy, China and Spain.
Men in the Republic account for 54pc of cases of the virus and they also make up the majority of those who have died of complications from this killer.
Among the 10 tragic deaths from the virus here on Thursday, seven were men.
So why are men so vulnerable to getting the infection and is there something in their lifestyle habits, state of health and biological make-up which makes them less able to fight the virus?
One of the suggestions put forward is that men are more inclined to be current or heavy smokers than women.
Dr Luke Clancy, director general of the Tobacco Free Research Institute in Ireland, said it is too early to come to major conclusions on the gender differences.
But smokers are more at risk of "getting into trouble" if they catch the virus, he pointed out.
They may be more likely to end up having to get breathing support from a ventilator.
The most recent smoking figures show 19pc of men in Ireland are still lighting up compared to 16pc of women.
Men also tend to be heavier smokers.
A report from the European Union agency on disease control this week also said smoking can make people more susceptible to serious complications from a coronavirus infection, and this applies to men and women.
Although the data is limited, the European Centre for Disease Control said smoking was associated with heightened activity of an enzyme in the lungs, ACE2, that could make patients more vulnerable to the virus.
This increases with age and with some kinds of blood pressure treatment.
Earlier this week, the Department of Health tightened up the criteria for those who can qualify for a coronavirus test. But the doctors added smokers to the list of priority groups who are eligible for a test if they have two major symptoms and been assessed by their GP.
Patients over 70 years of age and people with underlying conditions such as high blood pressure, diabetes or cardiovascular disease are among the most susceptible to virus and men are more vulnerable than women, the EU body said in its report.
However, smoking alone does not explain the higher risk for men.
It has been suggested that macho characteristics or certain occupations may mean they are less likely to follow the rules on handwashing or have the opportunity to do so.
They may be washing their hands but not for the required 20 seconds, using soap an warm water.
And as with a reluctance to seek help on other health matters, they may also be less inclined to stay at home if they develop symptoms.
Spending some leisure time in a crowded pub - when pubs were open - could make it easier to pick up.
The sex difference when it comes to the virus is exercising some of the best minds.
Experts at Johns Hopkins Bloomberg School of Public Health believe that something more than smoking is playing a role.
There may be a clue in men's immune responses to viruses which leave them at a disadvantage.
This has been found when it comes to HIV and Hepatitis C, although there has been no time yet to investigate if it applies to the coronavirus.
Men may not be as good as women in fighting off the virus when they make contact with it.
Women may also be helped by having higher levels of the hormone oestrogen, which can help boost immunity.
Of course, men can cut their risk by simply following the rules which apply to the wider population.
Stay at home if you can, and when you go out maintain a physical distance of two metres. Wash your hands and avoid visitors or visits to neighbours, friends or relatives.
Grandfathers need to physically avoid grandchildren and think up innovative and fun ways to keep in contact until all of this is over.
If a man has cold or flu symptoms, they should self-isolate for 14 days.