New protocols will be issued to employers across all sectors to ensure workers can return to work safely as the current restrictions are eased.
However, offices that have been lying empty while employees worked from home could now potentially be home to some rather unwelcome guests, like rats and mice.
Richard Faulkner, advanced technical field consultant with Rentokil, told the Irish Independent: "The thing with the shut down of buildings and businesses is animals want food and shelter.
"If we have all these buildings that are lovely and warm, quiet and undisturbed, you have got a stable environment, and that is all that any animal wants, especially the likes of the common rat and your house mouse, this is going to be ideal for them.
"When we open up these different businesses, we will probably find that the calls will escalate and they will be a lot, lot higher because people will be suddenly aware that they have problems in the buildings."
He said empty buildings provide a safe and secure harbour.
"Predators aren't going to come in after them in the building. They can breed in them," Mr Faulkner added.
"There will be certain buildings where there is going to be food residue and stuff there.
"When you look at buildings, when you have a hole or gap with a circumference of more than 5mm, a house mouse will get through that," he pointed out.
He added that vehicles can also be affected.
"A vehicle, especially if it's lying there, can become a home for a rodent."
People who can work safely while maintaining a two-metre distance from others can return to work in phase three of the Government's roadmap to ease the Covid-19 restrictions on June 29.
The Department of Business, Enterprise and Innovation and the Health and Safety Authority have been working with the HSE and Department of Health to finalise a Covid-19 'return to work safely' protocol.
A spokesperson for the department told the Irish Independent the protocol will be published shortly.
"It will set out the steps and measures that all employers and employees across all sectors must take to ensure adherence to public health measures and to mitigate the spread of Covid-19 in the workplace."
Meanwhile, a spokesperson for IDA Ireland said it has had regular, ongoing engagement with client companies advising them on the restrictions and HSE guidelines and offering guidance and assistance.
This included information on the Government supports available to businesses.
"Matters such as possible rodent infestations are however, an operational matter for the companies themselves," the spokesperson said.