Chelsea Clinton and her husband are expecting their first child later this year.
The daughter of former president Bill Clinton and former secretary of state Hillary Clinton announced at a Clinton Foundation event in New York that she and her husband, Marc Mezvinsky, are "very excited" to be having their first child later this year.
The former first lady said she is "really excited" about becoming a grandmother and it makes the work of empowering future generations even more important.
Ms Clinton, 34, who is vice chairman of her family's foundation, made the announcement at the end of an event on empowering young women.
She said last year in a magazine interview that she hoped 2014 would be "the year of the baby".