David Cameron is to enter negotiations with his three children to secure a 24-hour sugar and fizzy drink ban in Number 10.
The Prime Minister did not disclose when the Downing Street showdown with Nancy, Elwen and Florence will occur, although he has previously spoken of his battle to stop the trio drinking too much Coca-Cola.
The challenge has been made to Mr Cameron by Labour's Keith Vaz, who is waging a "war on sugar".
He urged the PM to raise awareness of diabetes and introduce measures to cut sugar levels in food and drink.
Speaking at Prime Minister's Questions, Mr Cameron told the Commons that the consequences of diabetes - including leg amputations - cost the NHS "literally billions of pounds a year".
He also acknowledged efforts to prevent diabetes and improve testing could help boost people's quality of life.
Mr Cameron replied to Mr Vaz: "I gather you also want me to try and ban sugar and fizzy drinks in Number 10 Downing Street for 24 hours. I will try and negotiate that with my children.
"You also, as I understand, want me to light my home blue, which is something I'm all in favour of and keeping it that way for some time to come."
World Diabetes Day takes place on November 14 and events include buildings being lit by blue lights.
Leicester East MP Mr Vaz had asked the PM: "In the last 12 months, it's estimated that 24,000 people have died from diabetes-related complications.
"Next Friday is World Diabetes Day. As one of the 3.2 million diabetics, can I urge you to do all you can to raise awareness on this issue, in particular to introduce measures that will reduce the amount of sugar in our food and drink?
"We can prevent the onset of type 2 diabetes and we can save lives."