Max Sorensen took four Scottish wickets before winning the match with a four as Ireland claimed a three-wicket win in the second one-day international in Dublin.
Sorensen took Ireland to 225 for seven with 34 balls remaining after he helped bowl the Scots out for 221.
Richie Berrington's unbeaten century had given Scotland a glimmer of hope after a dreadful start to their innings but the hosts did enough to claim an unassailable 2-0 lead in the three-match series.
Scottish openers Matty Cross and Calum MacLeod were both dismissed for four and Sorensen clean-bowled Preston Mommsen to leave the visitors in a mess on 11 for three.
Sorensen (four for 40) also took care of Hamish Gardiner and Freddie Coleman before the visitors had reached 50 but Berrington continued to rack up the runs to end on 101 not out and Josh Davey helped him out with 40 before Iain Wardlaw was run out for a duck from the penultimate ball of the innings.
Davey's bowling, and two catches from Cross, gave the Scots some hope by dealing with Irish openers Andy Balbirnie (16) and John Anderson (12).
But Kevin O'Brien's 67 put the hosts in command, Stuart Thompson (39) and John Mooney (27no) contributed and Sorensen finished the match in style.