They are ranked 174th in the world and have a population of just 165,000 are now two wins from two in the Asian qualifiers for the 2018 World Cup.
Guam, defeated 16-0 and 19-0 during the 2002 tournament qualifying, recorded their first ever qualifier win with victory over Turkmenistan last week and followed it up by beating India 2-1 at home.
The minnows sit top of Group D in round two of Asian 2018 World Cup qualification.
If Guam progress from this round of qualifying they play in an additional round, which sees 12 teams split into two groups of six.
The top two teams from each group will qualify for the World Cup. The two third-place teams will play home-and-away over two legs. The winner will advance to the inter-confederation play-offs.
Their coach Gary White said: "Our final outcome that we want is to put Guam football on the map, and I think that's happening already.
"And for the team to continue to develop. The prize, if you like, is to get to the World Cup, the Asian Cup, but we'll take each game at a time. It is a special time right now, I don't want to put an end on it. Can we qualify for the World Cup? We know it's going to be a tough road."