Video: Watch how David De Gea picked up his ankle injury in tonight's warm up
David De Gea was forced to pull out of their Europa League tie against FC Midtjylland after picking up an injury in the pre-match warm-up.
De Gea has been a shining star of United's campaign so far and was named in Louis van Gaal starting line-up for the clash against the Danish champions.
Yet word filtered through shortly before kick-off that Sergio Romero would take his place between the sticks for the first leg of the last-32 tie.
Initial reports suggested De Gea suffered a twisted ankle in the freezing conditions, with the severity of his problem to be assessed by United's medical staff in the coming days.
This is believed to be the moment when De Gea picked up his ankle problem:
With United set to face Shrewsbury in a crucial FA Cup fifth round tie on Monday, Van Gaal will be hoping his No.1 has not suffered ligament damage that would rule him out for an extended period.
Van Gaal is already struggling to get by with 13 of his first team squad in the treatment room, with Wayne Rooney the most recent high profile victim of the club's injury curse as is battling to recover from knee ligament damage.
Injury woes have been a theme of Van Gaal's troubled two years at Old Trafford, with question marks over the medical staff assembled by the Dutchman likely to be raised once more in the coming days.