Aston Villa (16) v Everton (15), 12.30
Tyrone Mings is available for Villa after a scan on an adductor muscle showed no serious damage. Emiliano Buendia will also be in the squad after a full week of training but Kortney Hause remains out with the injury that he picked up at the tail end of last season. Everton’s new signings Amadou Onana (pictured) and Conor Coady could make their first appearances for the club after arriving this week. Boss Frank Lampard will be without injured trio Dominic Calvert-Lewin, Yerry Mina and Ben Godfrey, with the latter ruled out for up to three months after fracturing a fibula.
Odds: H5/6; D12/5; A7/2
Ref: Michael Oliver (England)
Arsenal (3) v Leicester (11), 3.0
Emile Smith Rowe (hip), Takehiro Tomiyasu (quad) and Fabio Vieira (foot) are back in training for Arsenal, although the latter is unlikely to be risked. Winger Reiss Nelson is unavailable with muscular issue. The Foxes will be without Harvey Barnes, who has a knee problem, and Ricardo Pereira, who is facing six months out with a ruptured Achilles. Fellow defender Ryan Bertrand remains a long-term absentee.
Odds: H4/9; D17/5; A6/1
Ref: Darren England
Brighton (6) v Newcastle (5), 3.0
Brighton have no fresh injury concerns. Midfielder Jakub Moder (knee) is the only absentee for head coach Graham Potter, who is likely to stick with the same starting XI that won at Manchester United. Newcastle midfielder Jonjo Shelvey will be out for 12 weeks after undergoing surgery to address a hamstring problem. Jamaal Lascelles could return after a muscle problem, Jamal Lewis and Federico Fernandez (both calf) are working towards full fitness but fellow defender Emil Krafth (back) is likely to miss out.
Odds: H29/20; D9/4; A19/10
Ref: Graham Scott
Man City (4) v Bournemouth (2), 3.0
City will be without Kalvin Phillips while fellow midfielder Cole Palmer is a doubt – manager Pep Guardiola said Phillips is struggling with “niggles” and Palmer has a foot injury. Defender Aymeric Laporte is sidelined after knee surgery.
Bournemouth could have defender Marcos Senesi in the squad following his signing from Feyenoord. Experienced goalkeeper Neto could also be involved but fellow recruits defender Ryan Fredericks (calf) and midfielder Joe Rothwell (quad) remain a few weeks away from action.
Odds: H1/14; D9/1; A40/1
Ref: David Coote
Southampton (20) v Leeds (7), 3.0
Southampton have a major doubt over defender Lyanco, who has missed training this week because of a knee problem. Tino Livramento is Saints’ only long-term absentee.
Leeds are boosted by the return from injury of captain Liam Cooper, Adam Forshaw and summer signing Luis Sinisterra while Dan James is back from suspension. Junior Firpo (knee) is another two weeks away, while Stuart Dallas (fractured femur) and Luke Ayling (knee) are still out.
Odds: H5/4; D12/5; A21/10
Ref: Tony Harrington
Wolves (14) v Fulham (10), 3.0
Goncalo Guedes is in line for a Wolves debut following his midweek move from Valencia but injured pair Raul Jimenez (knee and groin) and Joao Moutinho (heel) are missing again. Nelson Semedo and Adama Traore (both hamstring) may not be risked as they work their way back to full fitness. Defender Issa Diop can make his Fulham debut after joining from West Ham but summer signing Manor Solomon is out with a knee injury which requires surgery. Fellow winger Harry Wilson is also missing.
Odds: H11/8; D9/4; A 21/10
Ref: John Brooks
Brentford (9) v Man Utd (13), 5.30
Mikkel Damsgaard will not be fit enough to start but could be in line for a debut off the bench. Ethan Pinnock, Kristoffer Ajer and Sergi Canos remain on the injury list.
United boss Erik ten Hag refused to be drawn on whether Cristiano Ronaldo would be fit enough to start. Fellow forward Anthony Martial and defender Victor Lindelof are injured.
Odds: H29/10; D12/5; A19/20
Ref: Stuart Attwell (England)
N Forest (18) v West Ham (19), 2.0
Forest have a doubt over defender Scott McKenna, who picked up an injury in training. Omar Richards has a hairline fracture in his leg while Ryan Yates is suffering with a knee injury. West Ham can hand a debut to winger Maxwel Cornet. Boss David Moyes will check on the fitness of goalkeeper Lukasz Fabianski and striker Michail Antonio, who picked up knocks last week. Defender Craig Dawson could return after a thigh injury.
Odds: H17/5; D12/5; A17/20
Ref: Robert Jones
Chelsea (8) v Tottenham (1), 4.30
Mateo Kovacic will miss out for Chelsea due to a niggling knee injury. Marcos Alonso will not feature either, with the wing-back attempting to finalise his transfer to Barcelona. Spurs are boosted by the availability of Richarlison (above), who sat out their opening-day win due to suspension.
Odds: H11/8; D11/5; A21/10
Ref: Anthony Taylor