With the Premier League's top six all playing at different times this weekend there is the prospect for plenty of chopping and changing - except at the top, where Chelsea are safe despite their match being on Monday.
Manchester United kick things off at home to Bournemouth on Saturday lunchtime, where a win would briefly take them into the top four ahead of Liverpool's hosting of Arsenal in the evening game.
Here, Press Association Sport looks at some of the issues of the weekend.
THE CONTINUAL RISE OF MANCHESTER UNITED
Jose Mourinho's side could cap a good seven days - having won the EFL Cup on Sunday - by breaking into the top four for the first time since early September. Their early start at home to Bournemouth gives them a chance to leapfrog both Liverpool and Arsenal, who meet at Anfield at 5.30pm. It will only be for a few hours as one of those two sides has to overtake them (a draw would put Arsenal back into fourth on goal difference) but it could be a psychologically important move.
WHICH LIVERPOOL WILL TURN UP AT ANFIELD?
Liverpool's surprise 3-1 defeat at Leicester on Monday reinforced all the stereotypes about Jurgen Klopp's side failing against lower-placed opposition, as all their five league defeats have been against teams in the bottom half of the table. Where they do excel, however, is against fellow top-six clubs and they have the best record of their rivals in that mini-league. Arsenal will not be defensive, like most sides who go to Anfield, and that could play into Liverpool's hands.
FOXES BACK UP AND RUNNING
Monday's victory over Liverpool in their first match since Claudio Ranieri's sacking was hugely important for Leicester's confidence. Caretaker manager Craig Shakespeare reverted to their title-winning formula and gained an immediate response so the visit of fellow strugglers Hull offers the perfect opportunity to build momentum and put some space between them and the relegation zone.
BLACK CATS NEED SOME LUCK
Sunderland are bottom of the table, have scored in only one of the last six matches (albeit four against fellow strugglers Crystal Palace) and their last home win was in mid-December. So the visit of Manchester City, who have scored five in each of their last two games against Monaco and Huddersfield, poses a real test for them. Manager David Moyes managed to squeeze a goalless draw out of the recent visit of Tottenham but City, with their tails up, are a different prospect.
IS COMPLACENCY A CONCERN FOR CONTE?
Leaders Chelsea can sit back and watch the weekend's events unfold, safe in the knowledge that at worst they will still have at least a seven-point cushion before they kick-off at West Ham on Monday evening. Antonio Conte's side appear to be heading serenely towards the title but a London derby is one to be wary of. The Hammers won an EFL Cup tie against an understrength Chelsea back in October, which should serve as a warning, but their league record against top-six sides is woeful.