Lionel Messi scored his 400th La Liga goal as leaders Barcelona claimed a comfortable 3-0 victory over Eibar at the Nou Camp to maintain their five-point advantage at the top of the table. Luis Suarez got the other two goals.
Messi's remarkable landmark strike came in just his 435th appearance in the competition.
Cristiano Ronaldo (311) is the only other player to have scored more than 300 goals in La Liga.
Antoine Griezmann scored from the penalty spot to give second-placed Atletico Madrid a hard-earned 1-0 win over Levante, while an 88th minute strike from Dani Ceballos gave Real Madrid a a 2-1 win at Real Betis.
Real are now joint third with Sevilla, who lost 2-0 at Athletic Bilbao to Inaki Williams' brace.
In Italy, promising young Argentinian Lautaro Martinez and Ivan Perisic stole the show as Inter Milan hammered Benevento 6-2 at the San Siro to book their place in the quarter-finals of the Coppa Italia.
Martinez notched two second-half goals, while Perisic had a hat-trick of assists.
Juventus took the first step towards a record fifth consecutive Coppa triumph with a 2-0 win over Bologna. Goals from Federico Bernardeschi and Moise Kean either side of the break gave an understrength Juve the win.
In France, Paris St-Germain dispatched Amiens 3-0 to make it 16 wins out of 18 league games.