England and Manchester United defender Luke Shaw faces a long spell on the sidelines as a result of his double leg break in Tuesday's Champions League match at PSV Eindhoven.
Here, Press Association Sport looks at six other young footballers to have experienced injury setbacks - and the results of their attempts to continue their career.
Three who recovered:
Suffered a double leg break in a Premier League match against Stoke in 2010 at the age of 19 but returned to the first team and remains an integral part of the squad, as well as being a key player for a Wales side who are on the brink of qualification for a major competition for the first time since 1958.
Liverpool striker Cisse was 23 when he broke his leg in a Premier League match at Blackburn in 2004. However, he was back in action in less than six months. Stints at Marseille, Sunderland, Panathinaikos, Lazio, QPR, Kuban Krasnodar and Bastia followed and, now aged 34, he has yet to hang up his boots.
Hutchinson made his Chelsea debut at the age of 18 in 2007 but retired from professional football aged 21, due to a recurring knee injury. However, he signed a new deal in 2011 following a "significant improvement" and is now on the books of Sheffield Wednesday, playing in Tuesday's match at Bolton.
Three who didn't:
Collett was 18 when he broke his right leg while making his first appearance for United's reserves against Middlesbrough in 2003. Boro player Gary Smith and his club admitted liability through their insurers before compensation of more than £4million was decided at Manchester's High Court.
Six weeks into Whiteside's apprenticeship at United he suffered a knee injury which ruled him out for seven months. A t 21 he required serious medical procedures to prevent an early retirement from the game and at 24 he joined Everton, but he w as forced to admit defeat and retire aged 26 in 1991.
Just three games into his captaincy of Manchester City, 21-year-old Lake picked up an injury against Aston Villa which was later confirmed as a ruptured anterior cruciate ligament. After several unsuccessful comebacks in a five-year injury struggle, he retired from football in January 1996.