Ireland will be without key forwards Tadhg Furlong and Iain Henderson for Saturday's pivotal Six Nations meeting with Wales.
The duo suffered hamstring injuries in the win over Italy two weeks ago and join Robbie Henshaw on the sidelines for the game having failed to recover in time.
Their absence sees Andrew Porter and James Ryan step into the side, with Chris Farrell replacing Henshaw in the centre. Cian Healy and CJ Stander come in for Jack McGrath and Jack Conan who drop to the bench.
Porter came on for Furlong after just three minutes against the Azzurri and did well, but this is a considerable step up for the 22-year-old who only switched from loosehead to tighthead last season and has made just five senior starts in the position.
Ryan was always expected to come back into the side after overcoming a hip injury, but the absence of Henderson means Devin Toner keeps his place.
The Ulster second-row has been an influential presence for the national team this season, acting as a play-maker at times and he will be a big loss.
Quinn Roux is on the bench, with John Ryan deputising for Porter.
Fergus McFadden replaces Jordan Larmour in the No 23 jersey.
"We are ready to test the strength of our squad and we are always ready to test the strength of our squad," Schmidt said.
"We're short on experience, we're up against a team welcoming back three Lions. It's not ideal, but there's no better place to learn than in that white hot atmosphere.
"We're going to have to demonstrate that we have a strength of squad and we are excited at the prospect of doing that."
More to follow
Ireland team to play Wales: (15-9) Rob Kearney, Keith Earls, Chris Farrell, Bundee Aki, Jacob Stockdale, Jonathan Sexton, Conor Murray; (1-8) Cian Healy, Rory Best, Andrew Porter, Devin Toner, James Ryan, Peter O'Mahony, Dan Leavy, CJ Stander.
Replacement: (16-23) Sean Cronin, Jack McGrath, John Ryan, Quinn Roux, Jack Conan, Kieran Marmion, Joey Carbery, Fergus McFadden.
It would be hard to argue with the man’s record. A win rate of more than 70 per cent, third in the world rankings, the first coach in the history of Irish rugby to lead the national team to a Test victory over the All Blacks, two Six Nations titles in four years and on course for a third this season – possibly even a Grand Slam if the stars align on St Patrick’s Day at Twickenham next month. Joe Schmidt is among the most successful coaches in world rugby. No question.