Ireland are without Garry Ringrose and James Ryan for this week's Six Nations finale against England.
Ryan has returned to Leinster having been removed for a Head Injury Assessment in yesterday's defeat to Scotland, while Ringrose suffered an ankle injury in the game.
This is the second match the second-row Ryan will miss in this year's Championship due to head injuries after he suffered a concussion against Wales.
Andy Farrell has called Peter O'Mahony up after he completed his ban for the red card in the opening match against Wales and he could come straight into the team in place of Ryan, with Tadhg Beirne switching to the second-row.
Alternatively, Farrell could bring Jack Conan off the bench with CJ Stander moving to blindside or he could retain the high-performing trio that started in Edinburgh and bring Ryan Baird into the side.
Bundee Aki is the most likely replacement for Ringrose, but Farrell could also call in Chris Farrell or Stuart McCloskey to partner Robbie Henshaw in the midfield.
Finlay Bealham has also been added to the squad after being part of the travelling party to Murrayfield last weekend.
Tom O'Toole has returned to the Ulster squad having picked up a knock in training last week.
Ireland squad for England game (Saturday, 4.45)
Bundee Aki (Connacht/Galwegians) 30 caps
Billy Burns (Ulster) 6 caps
Ross Byrne (Leinster/UCD) 12 caps
Craig Casey (Munster/Shannon) 1 cap
Andrew Conway (Munster/Garryowen) 24 caps
Keith Earls (Munster/Young Munster) 92 caps
Chris Farrell (Munster/Young Munster) 14 caps
Jamison Gibson Park (Leinster) 9 caps
Robbie Henshaw (Leinster/Buccaneers) 51 caps
Hugo Keenan (Leinster/UCD) 10 caps
Jordan Larmour (Leinster/St Mary’s College) 27 caps
James Lowe (Leinster) 6 caps
Stuart McCloskey (Ulster/Bangor) 4 caps
Conor Murray (Munster/Garryowen) 88 caps
Jonathan Sexton (Leinster/St Mary’s College) 98 caps
Jacob Stockdale (Ulster/Lurgan) 33 caps
Ryan Baird (Leinster/Dublin University) 2 caps
Finlay Bealham (Connacht/Buccaneers) 14 caps
Tadhg Beirne (Munster/Lansdowne) 21 caps
Ed Byrne (Leinster/UCD) 4 caps
Jack Conan (Leinster/Old Belvedere) 19 caps
Will Connors (Leinster/UCD) 9 caps
Ultan Dillane (Connacht/Corinthians) 18 caps
Tadhg Furlong (Leinster/Clontarf) 48 caps
Cian Healy (Leinster/Clontarf) 108 caps
Dave Heffernan (Connacht/Buccaneers) 5 caps
Iain Henderson (Ulster/Academy) 62 caps
Rob Herring (Ulster/Ballynahinch) 20 caps
Ronan Kelleher (Leinster/Lansdowne) 10 caps
Dave Kilcoyne (Munster/UL Bohemians) 42 caps
Peter O’Mahony (Munster/Cork Constitution) 74 caps
Andrew Porter (Leinster/UCD) 35 caps
Rhys Ruddock (Leinster/St Mary’s College) 27 caps
CJ Stander (Munster/Shannon) 50 caps
Josh van der Flier (Leinster/UCD) 30 caps
Tadhg Beirne is eyeing a rare opportunity as England’s revitalised chariot wheels into town this week after the Kildare man revealed he has never once tasted success against the old enemy in his entire career.