Peter O'Mahony has been recalled to the Ireland team to play Wales while Conor Murray once again gets the nod at scrum half.
ax Deegan is set to make his debut on Saturday, but will do so from the bench as Peter O'Mahony is recalled to the starting XV.
As expected, Caelan Doris misses out after picking up a head injury in the early stages of last weekend's win over Scotland.
The one other enforced change comes in midfield as Garry Ringrose is ruled out having undergone surgery on his thumb.
Robbie Henshaw has also been reinstated, having started on the bench against Scotland and renews his centre partnership with Bundee Aki.
Conor Murray again sees off the challenge of John Cooney to continue at scrum-half alongside captain Johnny Sexton.
Keith Earls has recovered from a knee injury, but Andrew Conway and Jacob Stockdale keep their places with Jordan Larmour again wearing the 15 jersey.
Tadhg Furlong was helped off the pitch last weekend after his calves cramped, but is fit to play to form a front-row with Cian Healy and Rob Herring.
James Ryan and Iain Henderson will continue in the engine room in front of the familiar looking back-row.
Ireland team (v Wales): J Larmour; A Conway, R Henshaw, B Aki, J Stockdale; J Sexton (capt), C Murray; C Healy, R Herring, T Furlong; I Henderson, J Ryan; P O'Mahony, J van der Flier, CJ Stander.