Andy Farrell is expected to keep faith with Peter O'Mahony and name the same starting Ireland team that beat Wales for Sunday's Six Nations clash against England.
That would see the head coach resist the temptation to put the fit-again Caelan Doris back into the starting XV as O'Mahony is rewarded for his recent resurgent form.
Doris is set to be named on the bench in place of Max Deegan, who is likely to drop out of the match-day 23 for the trip to Twickenham.
Keith Earls is pushing for a recall, but the Ireland back-three has a settled look to it with Jordan Larmour, Andrew Conway and Jacob Stockdale.
With Garry Ringrose again missing out with a thumb injury, Bundee Aki and Robbie Henshaw will renew their partnership in midfield.
Conor Murray will again see off John Cooney and continue alongside captain Johnny Sexton.
Up front, Cian Healy looks to have edged out Dave Kilcoyne for a starting spot as the Limerick man continues to force the issue.
Rónan Kelleher got some much-needed game-time for Leinster last weekend, but Rob Herring has played well in the opening two Six Nations wins and is likely to keep his place in the front-row alongside Healy and Tadhg Furlong.
A familiar engine-room will see Iain Henderson and James Ryan link up, with O'Mahony, Josh van der Flier and CJ Stander behind them in a tried-and-tested back-row.
Ireland will name their team to take on England at 1.50pm today.
Meanwhile, England have been dealt a major blow as they will be without prop Mako Vunipola, who is unavailable due to family reasons.
Ireland (v England) - J Larmour; A Conway, R Henshaw, B Aki, J Stockdale; J Sexton (capt), C Murray; C Healy, R Herring, T Furlong; I Henderson, J Ryan; P O'Mahony, J van der Flier, CJ Stander.