England will be without prop Mako Vunipola after the Saracens star was ruled out of the rest of the Six Nations after damaging ankle ligaments.
Vunipola was man of the match against Ireland on the opening weekend, delivering an impressive performance in England's comprehensive win.
The loosehead prop has been ruled out for ten weeks, and is set to miss Saracens' Champions Cup quarter-final against Glasgow as well as England's final three Six Nations games against Wales, Italy and Scotland.
England head coach Eddie Jones said: “It is obviously very disappointing to lose Mako at this stage as he is an important player for us but it does provide an opportunity for the team to grow.”
Elsewhere, Wales number eight Taulupe Faletau has undergone surgery on his broken arm to rule him out of the remainder of the Guinness Six Nations.
It was hoped Faletau would return for the final two rounds against Scotland and Ireland but Warren Gatland must complete the tournament without the Bath number eight.
"We're gutted for Taulupe, but this is the best course of action for him moving forwards as a player," Bath director of rugby Todd Blackadder said.
"We will know more in terms of time frames following the surgery, but we're looking forward to welcoming him back into the squad."