Jack Conan is on course to make it back for Leinster's Champions Cup quarter-final against Saracens, while Dan Leavy is making significant progress from his serious knee injury.
Senior coach Stuart Lancaster agreed the number eight could "potentially" make it onto the plane for the two PRO14 League matches in South Africa at the end of March.
"We're hoping Jack will be in or around that sort of time," said Lancaster.
"To get a player back of Jack's quality, and Max (Deegan) and Caelan (Doris) making their international debuts, it is a good place to be."
There is also positive news about Dan Leavy's dreadful knee injury.
"He is definitely on the right track, definitely," said the coach. "He has had fantastic physio and medical advice and opinion. And he has followed it to the tee.
"My chair looks over into the gym and for, I reckon, nine or ten months now, I've watched him day-in, day-out go from tiny, tiny steps in a brace to beginning to walk and move, getting his strength up.
"It's phenomenal really to see him getting back to the place he is now. I think he did his first run the other day.
"I think the (Champions Cup) quarter-final would be a stretch by a big mark. To turn it around in twelve months, or a little longer, would be amazing really.
In addition, Leinster will benefit from Ireland's release of Max Deegan, Dave Kearney, Ronan Kelleher, Luke McGrath, Will Connors ahead of hosting the Cheetahs on Saturday.
Connacht's Ultan Dillane and David Heffernan, Munster's Chris Farrell and Jack O’Donoghue and Ulster's Billy Burns, Stuart McCloskey, Jack McGrath and Tom O’Toole are also available for PRO14 action this weekend.