Devin Toner will start for Leinster against Benetton in the PRO14 League at Stadio Monigo tomorrow (KO 5.15pm Irish time, Eirsport 1).
The second row will get back to doing what he does best for the first time since failing to make Ireland's World Cup squad.
Ross Byrne and Dave Kearney will start in the backline with out-half Harry Byrne, Ross's younger sibling, set to make his debut from the replacements.
Hooker Ronan Kelleher will earn his third cap from the start and loose-head prop Michael Milne is also in line for his debut off the bench.
Meanwhile, Billy Holland will lead Munster out against Dragons to begin his 13th season at Thomond Park tomorrow (KO3.0 – TG4 & Eirsport).
Hooker Kevin O'Byrne starts the clash on his 50th Munster appearance.
Nick McCarthy makes his competitive debut for the province at scrum-half and partners JJ Hanrahan in the half-backs.
Tyler Bleyendaal and Rory Scannell team up in the centres with Mike Haley at full-back as wingers Darren Sweetnam and Shane Daly complete the back three.
Jeremy Loughman, O'Byrne and Stephen Archer pack down in the front row with Fineen Wycherley and Holland in the second row.
Prop Kenyan Knox and loose-forward Jack O'Sullivan are in line to make their competitive Munster debuts.
Elsewhere, Ulsterman Paddy McAllister will make his debut for Connacht against Scarlets in the PRO14 League tomorrow evening (KO5.15, TG4).
The loose-head won’t be lacking for support in the front row where Tom McCartney and Finlay Bealham are on duty.
The brothers Fitzgerald, Conor and Stephen, will also start with Conor taking the reins at out-half beside Caolan Blade, not long after Jack Carty plays for Ireland against Japan.
Captain Jarrad Butler will wear the now familiar number 8 jersey in a back row alongside Eoghan Masterson and Colby Fainga'a at blindside and openside, respectively.
LEINSTER (senior caps in brackets)
15. Jimmy O'Brien (7)
14. Adam Byrne (52)
13. Rory O'Loughlin (61)
12. Joe Tomane (13)
11. Dave Kearney (136)
10. Ross Byrne (71)
9. Jamison Gibson-Park (70)
1. Peter Dooley (61)
2. Rónan Kelleher (2)
3. Michael Bent (124)
4. Ross Molony (82) CAPTAIN
5. Devin Toner (231)
6. Max Deegan (46)
7. Will Connors (5)
8. Caelan Doris (16).
16. James Tracy (92)
17. Michael Milne (0)
18. Vakh Abdaladze (7)
19. Josh Murphy (21)
20. Scott Penny (6)
21. Hugh O'Sullivan (14)
22. Harry Byrne (0)
23. Hugo Keenan (5)
Munster: Mike Haley; Darren Sweetnam, Rory Scannell, Tyler Bleyendaal, Shane Daly; JJ Hanrahan, Nick McCarthy; Jeremy Loughman, Kevin O’Byrne, Stephen Archer; Fineen Wycherley, Billy Holland (Capt); Jack O’Donoghue, Tommy O’Donnell, Arno Botha.
Replacements: Diarmuid Barron, James Cronin, Keynan Knox, Darren O’Shea, Chris Cloete, Alby Mathewson, Liam Coombes, Jack O’Sullivan.
Connacht: Tiernan O’Halloran, Stephen Fitzgerald, Kyle Godwin, Tom Daly, Matt Healy, Conor Fitzgerald, Caolin Blade; Paddy McAllister, Tom McCartney, Finlay Bealham, Gavin Thornbury, Quinn Roux, Eoghan Masterson, Colby Fainga’a, Jarrad Butler (capt).
Replacements: Shane Delahunt, Denis Buckley, Dominic Robertson-McCoy, Ultan Dillane, Eoin McKeon, Kieran Marmion, Peter Robb, Darragh Leader.