Blues will be determined to make it nine wins from nine
Last time Leinster met Lyon, back in November, the French side were sitting at the summit of the Top 14 and looked almost unbeatable on home turf.
Leinster went to Matmut Stadium de Gerland and pulled out a 13-6 win on the most miserable of days in the south-east of France.
Since then, Lyon's form has not drastically tailed off but a couple of defeats on the road - to Montpellier and Castres - have seen them drop off of top spot. Bordeaux have overtaken them while a rejuvenated Toulon and Ronan O'Gara's La Rochelle sit in wait for any more slips.
Once finished with the Champions Cup pool next weekend, they will welcome the former followed by a Valentine's weekend top-of-the-table clash with Bordeaux.
For Lyon, travelling to the RDS Arena is even more daunting when you consider their record on the road in Champions Cup rugby - zero wins from five attempts.
On the flip side of that, Leinster have lost just one of their last 20 pool games, including winning their last eight in a row since losing to Toulouse last year.
This weekend, they'll be aiming to make that nine successive pool wins for the first time.