Ultan Dillane is set to miss Ireland's summer tour of America and Japan after he underwent shoulder surgery.
The lock had been touted as a potential Lions bolter before the Six Nations started but with the Irish tour a much more realistic target, the setback will come as a major blow.
Joe Schmidt is set to use the Tests against USA and Japan as an opportunity to blood some of the younger players and Dillane would have been amongst those eager to impress.
There had been some confusion over the Kerry native's fitness after he was omitted from the Ireland squad to play Wales but he was then added before the injury was fully revealed.
The IRFU initially said that Dillane was looking at eight to ten weeks on the sidelines but his chances of being included on the tour now seem to be over.
Connacht yesterday confirmed that the surgery had been a success but the 23-year-old will not play for the province again this season.
"I'd say very unlikely (that he will make the tour), if he hasn't played any rugby," Pat Lam admitted.
"All he can control is get the injury right and prepare well for pre-season for Connacht. Start the Pro12 really well, and then put himself in the frame for international selection which is miles away now. It's an injury that he will come back stronger from."
Meanwhile, Munster second-row Dave Foley will join Top 14 side Pau next season.
Ireland legend Brian O'Driscoll is disappointed that Joe Schmidt's squad didn't enjoy a knees-up together the day after they ended England's dream of back-to-back Grand Slams and the world record for consecutive wins against tier one nations.
Leinster are sweating over the fitness of Jamie Heaslip and Rob Kearney ahead of their Champions Cup quarter-final clash with Wasps on Saturday week but the province has allayed fears surrounding Johnny Sexton.
Saturday's win over England saw Ireland finish a disappointing but compelling Six Nations with a flourish and secure a second-place finish behind Eddie Jones's champions. Joe Schmidt used 33 players over the course of the tournament, here's how they rated.