Joe Schmidt says it is too early too say if Joey Carbery's ankle injury will affect his World Cup chances, but the Ireland coach is upbeat on his chances of recovering in time.
The head coach confirmed that his out-half had not fractured his ankle in a second-half collision and will await news of a scan on the ligaments.
He retains some hope that the Munster star, who was Ireland's best player in their win over Italy, will be fit to face England in two weeks' time.
"The good news is there's no fracture, it's a bit puffy on the inside of his left ankle," said Schmidt.
"We'll give it 24 to 48 hours for the swelling to go down.
"He's been cleared of a fracture so that's the good news on Joey.
"We don't have anyone else who's a major concern.
"We're hopefully relatively unscathed but Joey it will take 24 to 48 hours to know for sure.
"I was really happy with Joey's performance today.
"Defensively he got himself into the right places, and that's a challenge sometimes.
"I thought he ran the game very well, the variety of his kicking game and running game.
"He is a danger with the ball, and he almost got through the line a couple of times.
"I thought as a package Joey's game was really tidy."
Ireland boss Schmidt confirmed Sexton will be available to feature in the next warm-up clash, against England at Twickenham on Saturday, August 24.
"Johnny probably could have played this weekend," said Schmidt.
"He trained in the week and was going pretty hard I'm told."
Meanwhile, Schmidt said that hooker Rob Herring's back injury is not overly serious. The Ulsterman was taken off after 20 minutes of the game.
"Rob Herring had a bit of a back spasm, a bit of a back strain. It isn’t anything too major, not of massive concern to the medical team," he told RTE.
Carbery, Dave Kearney, Andrew Conway, Jordi Murphy and Kieran Marmion all crossed as an experimental Ireland line-up secured a routine Aviva Stadium victory.
Maxime Mbanda and Carlo Canna bagged first-half tries as Italy exploited Ireland's pre-season ring-rustiness.
Chris Farrell impressed at inside centre, providing stability and power across Ireland's midfield.
And Schmidt admitted the Munster powerhouse has improved his chances of forcing his way into Ireland's final World Cup 31.
Asked if Farrell had improved his abilities to feature at either 12 or 13, Schmidt said: "I think he took a step toward it.
"It's something that we know all three of the other centres can do.
"Garry Ringrose started his first Test as a 12, and coming off the bench before he's shifted into 12.
"Bundee has played a lot of 12, and Robbie too.
"And at the same time those three players can play 13.
"So we want to make sure that three or four centres, however we carve it up, with Garry able to play on the wing as well. So it's just keeping our options open a little."
Italy boss Conor O'Shea insisted he was reasonably satisfied with proceedings, despite the defeat.
"It's very hard to contextualise when you have your first hit-out," said O'Shea.
"I thought there were a lot of positives for where we are physically; we were able to more than hold our own.
"It comes to the stage now about what we can control, not what the opposition does to us.
"A few guys really stuck their hands up; we'll just keep on building."
These warm-up games are fraught with danger and the sight of Joey Carbery, head in hands, coming off the Aviva Stadium pitch on a stretcher was exactly the kind of sight Joe Schmidt didn’t want to see as he arrived back from New Zealand in time to take charge of this win over Italy.
Australia gave themselves a huge boost ahead of the World Cup when they stunned a New Zealand side reduced to 14 men for half the match 47-26 in a thrilling Rugby Championship test in Perth on Saturday.