Out-half Ellen Murphy is a doubt for Ireland's Six Nations tussle with Wales at Energia Park on Sunday.
It would come as a serious setback were the 24-year-old unable to make it back as they are in the middle of nailing down the fundamentals of an exciting, expansive style with Murphy in control of the game plan.
The playmaker was forced off with a calf injury against Scotland, pushing coach Adam Griggs into a backline reshuffle.
Should Murphy fail to recover, it could well fall on Sene Naoupu to move into the number ten shirt, although Larissa Muldoon has been summoned as cover for Murphy.
Griggs has also called the uncapped Neve Jones into an extended Ireland squad of 27 to prepare for the Welsh.
The Ulster hooker has been promoted in light of first choice Cliodhna Moloney going through the return-to-play protocols after a head knock against the Scots.
The timeline makes Moloney a 50/50 chance, at best, to make it and Victoria Dabanovich-O'Mahony could well be in line for a first start in the championship.
The experienced back-three operator Eimear Considine will be given the leeway to prove her fitness at training on Thursday and Friday.
Hannah Tyrrell slots straight into the group after concluding the latest leg of the World Sevens Series in Sydney.
Ireland have already played Wales twice this season, losing in Dublin in November and winning last month in Wales.
Griggs is scheduled to release the Ireland team on Friday morning.
IRELAND WOMEN'S SQUAD (v Wales):
Backs (13): M Claffey, E Considine, N Cronin, K Dane, L Delany, A Doyle, C Keohane, L Muldoon, E Murphy, S Naoupu, B Parsons, L Sheehan, H Tyrrell;
Forwards (14): A Caplice, C Cooney, V Dabanovich-O'Mahony, L Djougang, L Feely, N Fryday, C Griffin (capt), N Jones, L Lyons, A McDermott, E McMahon, C Moloney, L Peat, D Wall.