Ireland coach Joe Schmidt won't run risks with Robbie Henshaw
Ireland boss Schmidt is confident Henshaw will be ready to face Italy despite leaving the 21-year-old out of Sunday's Pool D clash at Wembley.
Henshaw failed to recover from hamstring trouble in time to contest selection for Ireland's second World Cup encounter, with head coach Schmidt making 12 changes from the side that thrashed Canada 50-7.
Darren Cave slots in at 12 with Cian Healy back in at loosehead prop, with Ireland naming their oldest-ever World Cup starting line-up.
"It was just that at the start of the week we felt we had to take it a little bit easier than we first thought with Robbie," said Schmidt.
"He is fully running now and we just felt we'd rather not push ahead.
"Soft tissue injuries can be quite complicated.
"If you get a re-injury on the same site then you are in a situation where his World Cup could be in doubt.
"So we've taken no risk.
"There are times to take risks but this is a great opportunity for Darren Cave."
Romania lost out 38-11 to France at London's Olympic Stadium on Thursday night and will be pressed into action four days later against Ireland.
Uneven rest periods have once again become a World Cup bugbear, with Japan suffering 45-10 defeat to Scotland just four days after stunning South Africa and the world with a 34-32 victory in Brighton.
Schmidt was keen not to accept his side gain an unfair edge against the world's 17th-ranked side this weekend - but did admit Ireland will take any help they can get.
"I don't know if it gives us an unfair advantage, that's something you might attach to it," said Schmidt. "But for us the draw is the draw.
"That's just the draw - that's the reality."
Johnny Sexton, Peter O'Mahony and Iain Henderson all returned to full training for Ireland on Friday after light knocks, but those three were never going to be called upon to face Romania in any case.
Surprised to learn Ireland had set a new record with their oldest starting XV at the tournament, Schmidt joked that 34-year-old scrum-half Eoin Reddan may have skewed the stats.
"Well Eoin Reddan has probably contributed to that! Is it really?" said a bemused Schmidt. "Hopefully the team won't show its age!"
Schmidt has named four World Cup debutants in his side to face Romania, Richardt Strauss, Devin Toner, Jordi Murphy and Cave making their tournament bows in London.
Henshaw will remain the only man of Ireland's squad not to feature in the competition so far should Schmidt empty his full bench at Wembley.
Versatile playmaker Ian Madigan will start at fly-half, but Schmidt admitted the Leinster pivot could move to scrum-half during the course of the match.
Madigan is Ireland's third and emergency scrum-half, covering for Conor Murray and Reddan, with Schmidt keen to hand him a first Test run at nine this weekend.
"We want Ian (Madigan) and Paddy (Jackson) both to have some time at 10," said Schmidt.
"But if the game's going in a direction where we feel Ian would benefit from 15 minutes at nine, then that's possible."