Sir Isaac Newton, which is as low as 10/1 for the Investec Derby, makes his eagerly-awaited reappearance in the Maiden Stakes at Chester today.
The Galileo colt is a full brother to Ralph Beckett's Oaks runner-up Secret Gesture and made a very pleasing debut for Aidan O'Brien at Leopardstown last October, finishing a half-length second to Dermot Weld's Zawraq, which is currently second favourite for Epsom.
Sir Isaac Newton faces seven rivals, including John Gosden's Derby entry Keble, which finished second to Intilaaq at Newbury last month.
"He's had only one run and we were taking our time with him. He's a horse we've thought a lot of and he has a lot of speed," said O'Brien.
"You wouldn't rule out an Irish Guineas with him, but he probably has a lot to learn in a short space of time if he is going to be a Classic horse having only had one run.
"We always feel they learn a lot in Chester and come out of it very well. We'll let that happen and deal with it after that. He's a horse with a lot of pace, he could come back to an Irish Guineas if we needed him - Magician did that (after winning at Chester)."
Dermot Weld likes to have a runner in the Chester Cup and saddles the dual-purpose performer Zafayan in today's marathon test.
Weld wanted to run the four-year-old at Cheltenham, but he failed to make the cut so he ran on the Flat at Leopardstown and won easily.
Marco Botti admits Ryan Moore is going to have to weave his magic from stall 16 if Suegioo is to repeat his victory of 12 months ago.
One of five runners for owner Marwan Koukash, the six-year-old is 9lb higher than last year, when he came late to beat Angel Gabrial, another Koukash runner, which also tries his luck again today.
Meanwhile, Nicky Henderson is considering giving Finian's Rainbow and Simonsig surprise appearances at Killarney next week. Finian's Rainbow could go for the Leane's Tool Hire & Lawnmowers Chase over an extended two-and-a-half miles on Sunday, while Simonsig is to be given an entry in a two-and-a-half-mile hurdle next Monday.
Simonsig was last seen winning the Arkle Trophy in March 2013 before a splint injury caused the talented grey to miss the 2013-14 season.
Finian's Rainbow, which lifted the Queen Mother Champion Chase in 2012, has been absent since he struck into himself in the Paddy Power Gold Cup in November 2013.