First-half goals from Nicole Fortune and Bríd Gordon laid the foundation as Wexford inflicted a first defeat since last April on Littlewoods Ireland Camogie League Division 1 and All-Ireland champions Kilkenny.
Linda Bolger added nine points at the Naomh Éanna facility in Gorey as the home side prevailed by 2-11 to 0-9.
Meanwhile, Beth Carton lit up Parnells GAA in Coolock, the UL first year providing nine points as Waterford beat Dublin 0-11 to 0-7.
In Group 2, Galway came away from Birr with a 1-11 to 1-4 win. Much of the action came in the first quarter, with Galway getting the scoring under way thanks to Catherine Finnerty, making her first start since the 2015 All-Ireland final.
Chloe Morey was in red-hot form for Clare, when contributing 1-12 in the Banner women's 2-14 to 1-9 defeat of Meath. Niamh O'Dea scored the other goal and that was enough to resist the Royals.