Tyrone turned on the power in the final quarter as they came from behind for a convincing win in the Dr McKenna Cup at Healy Park.
Queen's trailed by three points at the break after failing to convert three golden goal chances.
Tyrone went 0-4 to 0-2 up, thanks to neat scores from debutant Johnny Lafferty .
The lively Donal O'Hare hit the target twice for Queen's, and Mark Sweeney's point narrowed the gap to one. But Tommy McGuigan and Martin Penrose gave the Red Hands a 0-6 to 0-3 interval lead.
Queen's did get in for a goal early in the second half when O'Hare sent Caolan Rafferty in for a cool finish, and went ahead through Sean Warnock.
But the home side stepped up the tempo in the final quarter. Teenage sub Ronan O'Neill's 51st-minute goal was followed by a string of points from Peter Harte, Aidan Cassidy, Niall McKenna and Colm Cavanagh as Tyrone pulled away.
scorers -- Tyrone: R O'Neill 1-0, J Lafferty, T McGuigan (3f) 0-3 each, A Cassidy, P Harte (1 '45') 0-2 each, C Cavanagh, N McKenna, M Penrose 0-1 each. Queen's: C Rafferty 1-0, D O'Hare 0-2, M Sweeney, T Hanna, S Warnock 0-1 each.
Tyrone -- J Devine; PJ Quinn, J McMahon, D McCaul; S O'Neill, P Harte, S McNally; A Cassidy, C Cavanagh; M Donnelly, M Penrose, M Murphy; P McNeice, J Lafferty, T McGuigan. Subs: R O'Neill for McNeice, D Carlin for McNally, N McKenna for Donnelly.
Queen's -- M Jackson; N McGovern, S Warnock, O Costello; T Hanna, B Cox, P McGuigan; M Sweeney, E Clarke; A Murnin, R Jones, G Jordan; J O'Reilly, D O'Hare, C Rafferty. Subs: C Morgan for Jordan, C Fleming for McGuigan, CC Sheerin for Warnock.
Ref -- N Mooney (Cavan)