Striker Kevin Doyle has withdrawn from the Republic of Ireland squad for the Euro 2016 qualifier against Scotland at Celtic Park on Friday.
Doyle, who is currently on loan at Crystal Palace from Wolves, was unable to train with his Ireland team-mates at Gannon Park in Malahide on Tuesday morning because of a groin injury, and is to return to his club for treatment.
A Football Association of Ireland spokesman said: "The Football Association of Ireland today confirmed that Kevin Doyle has withdrawn from the Irish squad, and will return to his club for treatment on a groin injury."
Manager Martin O'Neill has no immediate plans to call up a replacement as he prepares for the Group D clash in Glasgow and the friendly against the United States which follows it next Tuesday.
Midfielder James McCarthy and defender Stephen Ward also sat out the session with the Everton man's hamstring problem a concern, but Stoke counterpart Glenn Whelan was able to train just weeks after breaking a bone in his leg during last month's 1-1 draw in Germany.