Gareth Southgate says England will miss "absolute soldier" Kieran Trippier against Denmark, with the right-back unavailable as he deals with a Football Association hearing for alleged betting breaches.
The 30-year-old was one of the stars of the Three Lions' run to the 2018 World Cup semi-finals and skippered his country for the first time in last Thursday's 3-0 friendly win against Wales.
Trippier was one of only two players to retain a starting berth against Belgium on Sunday, with the full-back playing the full 90 minutes of the impressive 2-1 victory against star-studded Belgium.
But the Atletico Madrid defender will not complete England's triple-header after leaving the camp to face an FA hearing for allegedly breaching betting rules in July 2019.
"There is not a lot I can say about that, really," Southgate said of Trippier's withdrawal from the squad at the same time as Chelsea left-back Ben Chilwell through injury.
"It is not something that is in my control so I have got to focus on preparing the team with the players I have got available.
"We always find solutions. It is an opportunity for somebody else and if I lose focus on the job in hand... there are a million distractions, frankly.
"This is another distraction but it is something I have got to plough on through."
Trippier moved from Tottenham to Atletico Madrid in July 2019 and was charged in May with alleged breaches of the FA's betting rules during that month.
The right-back released a statement saying that he would continue to fully co-operate with the investigation and Southgate would "have liked to have had Kieran available" at Wembley tonight.
"I think the less I say the better," the England manager said. "But I think what is clear is I don't have any influence on disciplinary procedure, which I think is correct.
"I can't be influencing when things happen or how they play out.