REAL Madrid suffered a second successive defeat as Atletico Madrid and Barcelona pulled clear in the Primera Division title race, but Barca's night was marred by a serious injury to goalkeeper Victor Valdes which has likely ended his career with the club.
Sevilla came from behind to beat Madrid 2-1 as leaders Atletico were seeing off Granada 1-0, while earlier in the evening Barca had followed up their 4-3 Clasico victory by beating Celta Vigo 3-0.
Barca's celebrations were muted after the Valdes news came through.
Barca confirmed that Valdes had suffered an anterior cruciate ligament tear after the match.
Orellana's free-kick appeared to catch Valdes wrong-footed, and although he was able to make the stop he had to dive forward to gather the rebound, and it was then he suffered the injury.
At that point, Barca were already leading 1-0 through Neymar's sixth minute goal, and Lionel Messi doubled the advantage on the half hour before Neymar struck again midway through the second period.
In Seville, Cristiano Ronaldo put Madrid in front with a 15th minute deflected free-kick after he had been fouled by Andujar Coke, but Sevilla replied almost immediately through Carlos Bacca, and in the 72nd minute some superb skill from Ivan Rakitic set up Bacca for the second.
It was a record sixth straight win for Sevilla, lifting them up to fifth, six points behind Athletic Bilbao in fourth.
Atletico lead the way on 73 points after Diego Costa's 63rd minute header was enough to give them all three points at home.