Tottenham striker Harry Kane has damaged lateral ligaments in his right ankle and is expected back in training next month, the Premier League club announced on Wednesday.
The England forward suffered the problem during Sunday's 4-1 win at Bournemouth.
A scan to establish a clearer picture of the full extent of his injury had been delayed because of swelling around the joint.
In a brief statement posted to the club's official website on Wednesday afternoon, Tottenham said: "Preliminary assessments have confirmed that Harry Kane has damaged lateral ligaments in his right ankle.
"The England striker sustained the injury following a challenge in our 4-1 win over Bournemouth on Sunday and is expected to return to First Team training next month."
Kane was pictured with his foot in a brace and using crutches when out in Essex on Monday.
Both Tottenham and England will be wary of Kane's previous history of ankle injuries, the forward having suffered ligament damage to the same joint twice last season.
Despite concerns over how long Kane may be out of consideration for - with the World Cup just three months away - his previous ankle problems were of differing severity and time-frames for recovery.
The first one kept the forward out for 10 games, from mid-September to early-November 2016.
However, Kane was able to return within a month of the second injury, back playing on April 8 and soon among the goals again before going on to lead the England attack in their June internationals.
Kane, who has scored some 39 goals this season for club and country, will now miss Spurs' FA Cup quarter-final at Swansea on Saturday. Manager Mauricio Pochettino will hold a press conference to preview the cup tie on Thursday at 12:30pm, when the issue of Kane's likely recovery schedule is expected to be raised.
Whatever the full prognosis, the forward will not be fit for England duty during next week's international break, with the Three Lions set to face Holland and Italy in friendlies.
Tottenham are back in Premier League action following the international break with a trip to top-four rivals Chelsea on April 1. Kane's history of ankle injuries will have no impact on his recovery from his latest problem, says former England physio Alan Smith. "It's not uncommon in football to have an injury of that nature," he said.
"I saw the incident and that would sprain anybody's ankle. The goalkeeper's body weight went into his ankle, so that would have injured anyone, with or without previous history. It comes down to strengthening the ankle joint from the original injury.
"He shouldn't be more susceptible to it reoccurring, you have to get the thing 100 per cent right, clinically and functionally correct and then it won't reoccur unless there is another traumatic incident, like the one with the goalkeeper."