Unai Emery has urged his Arsenal players to seize the moment and beat Spurs today to move within a point of their neighbours.
The Gunners head to Wembley knowing they can close right up on third-placed Tottenham.
After three successive wins Arsenal head into the third north London derby of the season in top form.
In contrast, Tottenham were beaten at Burnley and Chelsea in their last two games, dropping out of the title race and into a potential scrap to finish in the top four.
Gunners coach Emery knows securing Arsenal's first away win over their biggest rivals since 2014 is a difficult one but believes recent form should give his players all the confidence they need.
"We've been speaking about the opportunity and each match gives us the opportunity to win three points," he said.
"Sometimes we can take the big opportunity like tomorrow because there were 10 points difference between us and Spurs two weeks ago. Now it's four points.
"Tomorrow we are going to play together. This is a big opportunity for us to play with confidence. We respect them. They lost two matches but they are still having a very good season.
"We will prepare to deliver the best performance individually and collectively. We need to be strong and very concentrated over 90 minutes.
"We want to play with confidence and also free in our minds, with a focus on our game plan. All individuals can have this confidence.
"When we get our chances, we need to be efficient."
Emery also insisted he did not have to put any work in on mentally preparing his players for the big derby. "The players know that it's important because we want to get three points to improve in the table," he added.
"Then afterwards, it's special for the supporters. We are playing for three points and more tomorrow.
"It'll be different for us because it's away and more against their supporters.
''For us to prepare, it's about thinking about the best Tottenham, and thinking we need to be strong going into the match."
It will also be a special occasion for Emery as he takes charge of a team at Wembley for the first time.
Asked if he was excited to be managing at Wembley, he replied: ''Yes. I'm looking forward to playing the match and watching our performance.
''Hopefully we can enjoy 90 minutes with a very big atmosphere.
"We know our supporters are going to be there with us. Together, we can be concentrated on doing the rest."
Arsenal are likely to have captain Laurent Koscielny available after he shook off a knock to his knee in Wednesday's 5-1 thrashing of Bournemouth, while Stephan Lichtsteiner is also fit following a back problem.