Chairman Pete Winkelman has described the visit of Manchester United as the biggest game in MK Dons' short history.
Winkelman also believes the expected 29,000 sell-out for the Capital One Cup second-round tie on Tuesday night will provide an indication of the club's potential.
It is 11 years since Wimbledon FC relocated more than 50 miles north of their south-west London home to the Buckinghamshire town of Milton Keynes. The name was changed to MK Dons the following year in 2004.
During that time, Premier League teams have visited stadium:mk, but none of the stature of the 20-time English champions.
Winkelman said: "It's a terrific way to mark the 10-year anniversary of the club. It's taken us that long to get a really, really great cup draw. It will be the biggest game in the club's history."