AS an Atletico Madrid striker, Sergio Aguero never finished on the winning side against bigger city rivals Real but he hopes to break his duck in a Manchester City shirt tomorrow night.
The Argentina international spent five years with Atletico, scoring 74 goals in 175 games, and although some of those strikes came against the Galacticos it was never enough to secure victory.
Aguero hopes that drought will end in order to keep City's slim Champions League chances alive. "It's always special to play against a club like Real Madrid," he said.
"Personally, my connection with Atletico Madrid gives it an additional kick - but there's no difference in how much I want to win this match.
"Never defeating Real when I was with Atletico was a real regret for me -- Atletico haven't succeeded in beating them for many years - but I did get to score against them even if we never managed a win. Wednesday night will hopefully break that run for me."
Bottom of Group D with two points, five behind their opponents, City have to beat Real to avoid a second successive group stage elimination.
Even if they do prevail at the Etihad Stadium, Roberto Mancini's side would then have to beat Borussia Dortmund and hope other results go their way.
"We should never give up. Where there's a will, there's a way, right?" Aguero said.
"Of course, it's harder now because we're not just relying on ourselves but also on the other teams' results.
"I think it's even more significant now than if we had been in a better position in the table.
"It may sound strange but I firmly believe that. We must win this game.
"Whatever the final scoreline is - a good one, I hope - we'll show on the field that we don't give up, like we did in the game against Ajax and in every game we've played.
"We have a great team, I have no doubt about it and now it is time for us to show just how good we are.
"What we mustn't do is leave the pitch with any regrets and be content knowing that we have given our all."