Harlequins have lost Chris Robshaw and Nick Evans to injury.
The England captain will see a specialist to examine the extent of the damage done to his shoulder last Saturday.
Out-half Evans retired in the first quarter with a leg injury that seemed to impede his kicking.
This is the sort of double blow Conor O'Shea is not really equipped to deal with given the limited resources at his disposal.
Nevertheless, 'Quins and the mighty Toulouse are the only two remaining unbeaten clubs in The Champions Cup at the halfway point of the Pools.
On the domestic front, however, 'Quins are sitting pretty uncomfortably in ninth place, four off the bottom rung of the ladder.
The London club has lost more (5) than it has won (4) from nine rounds of The Premiership.
This was perfectly encapsulated in their Jekyll-and-Hyde smashing by Bath last Friday week and their smashing of Leinster in Europe last Saturday.
"Considering what happened against Bath the week before, the way we turned it around was great," said George Lowe.
The 25-year-old centre (pictured) highlighted the scrum power of Joe Marler and Will Collier as a primary weapon which they have used well for most of the season.
"It has been a massive strong point for us for the majority of the season.
"Against Wasps in Europe and Gloucester at Kingshom, it was really impressive.
"It was just that Bath game where it went wrong. But, we took our first opportunity to bounce back."
While Leinster will be stewing in anger and waiting for redemption at the Aviva Stadium, Harlequins will travel with optimism and realism that they can go back-to-back.
"We are really happy with how we played last weekend, but we also know that it's only half the job done," he continued.
The news that Robshaw and Evans are out makes the job a whole lot harder.