Wing Andrew Trimble and hooker John Andrew are the two new faces for Ulster against Scarlets in West Wales this evening (KO 7.35, BBC2).
Skerries native Alan O'Connor will captain for the third game in a row alongside Kieran Treadwell in the second row.
Flanker Nick Timoney and scrum-half John Cooney are the two other former Leinster men chosen.
They will have to be on top of their game to put it up to Scarlets, especially in the back row where Tadhg Beirne and James Davies will lurk for turnovers.
Connacht will have flanker Jarrad Butler and prop Denis Buckley back away to Benetton at Stadio Monigo at lunchtime today (KO 12.0, TG4).
Galway boys Sean O'Brien and John Muldoon will join Butler in the back row against the in-form Italians.
"We will need to be at our best if we want to win," said coach Kieran Keane.
Scarlets: T Williams; C Baldwin, P Asquith, S Hughes (capt), I Nicholas; D Jones, J Evans; D Evans, R Elias, W Kruger, S Cummins, D Bulbring, T Beirne, J Davies, J Macleod.
Ulster: L Ludik; A Trimble, L Marshall, S McCloskey, T Bowe; J McPhillips, J Cooney; A Warwick, J Andrew, W Herbst, A O'Connor (capt), K Treadwell, M Rea, N Timoney, J Deysel.
Benetton: L Sperandio; A Bronzini, T Iannone, L Morisi, M Ioane; M Banks, T Tebaldi; F Zani, T Baravalle, M Zanusso, M Lazzaroni, I Herbst, A Sgarbi (capt), M Barbini, W Douglas.
Connacht: T O'Halloran, C Kelleher, E Griffin, T Farrell, M Healy; J Carty, C Blade; D Buckley, T McCartney, F Bealham, G Thornbury, J Cannon, S O'Brien, J Butler, J Muldoon (capt).