Coach Rob Penney has made four changes from the side that pushed Saracens all the way at Vicarage Road before Christmas.
Keith Earls, Dave Kilcoyne and Tommy O'Donnell all return from injury to take over from Casey Laulala, Wian du Preez and Dave O'Callaghan, respectively.
Although hooker Mike Sherry has been deemed fit enough to play, Damien Varley takes over in what is a touch-and-go selection between two players who bring different strengths to the role.
Munster will want to do to the Scots what Leinster did there last week. Half-backs Conor Murray and Ronan O'Gara have to offer more than astute kicking.
Centre James Downey will take them over the gain line. Wings Simon Zebo and Doug Howlett in tandem with Earls can take it from there.
Richie Rees and Greig Laidlaw renew their half-back partnership and centre Ben Cairns is the third change.
Edinburgh: G Tonks; D Fife, B Cairns, M Scott, T Visser; G Laidlaw (capt), R Rees; A Jacobsen, S Lawrie, W Nel, G Gilchrist, S Cox, S McInally, D Basilaia, D Denton.
Munster: F Jones; D Howlett (capt), K Earls, J Downey, S Zebo; R O'Gara, C Murray; D Kilcoyne, D Varley, BJ Botha, D O'Callaghan, D Ryan, P O'Mahony, T O'Donnell, J Coughlan.