Leinster winger James Lowe looks set to make his Ireland debut against Wales tomorrow week after he formally became part of Andy Farrell's squad.
The head coach has largely stuck with the same panel that contested the final two Six Nations games against Italy and France, with fit-again Keith Earls back and Iain Henderson restored after his ban.
Ulster out-half Billy Burns replaces Jack Carty, while Leinster No 8 Jack Conan remains with Leinster to rehab an unspecified injury.
Ireland are still without Tadhg Furlong and Ryan Baird who may come back into contention during the tournament that sees them face Wales, England and Georgia, before they take on one of France, Italy, Scotland or Fiji in a final match on December 5.
Lowe is the latest player to qualify under World Rugby's residency laws.
His addition greatly adds to Farrell's back three options, with Earls' experience also a factor as the coach looks to bounce back from the loss in Paris last Saturday.
Johnny Sexton continues to captain the team despite his controversial reaction to being substituted at the Stade de France.
Ireland Squad Guinness Series/Autumn Nations Cup
Backs (16): Bundee Aki (Connacht), Billy Burns (Ulster), Ross Byrne (Leinster), Andrew Conway (Munster), Shane Daly (Munster), Keith Earls (Munster), Chris Farrell (Munster), Jamison Gibson Park (Leinster), Robbie Henshaw (Leinster), Hugo Keenan (Leinster), James Lowe (Leinster), Kieran Marmion (Connacht), Stuart McCloskey (Ulster), Conor Murray (Munster), Jonathan Sexton (Leinster), Jacob Stockdale (Ulster).
Forwards (18): Finlay Bealham (Connacht), Tadhg Beirne (Munster), Ed Byrne (Leinster), Will Connors (Leinster), Ultan Dillane (Connacht), Caelan Doris (Leinster), Cian Healy (Leinster), Dave Heffernan (Connacht), Iain Henderson (Ulster), Rob Herring (Ulster), Ronan Kelleher (Leinster/Lansdowne) 3 caps, Peter O'Mahony (Munster), Andrew Porter (Leinster), Quinn Roux (Connacht), John Ryan (Munster), James Ryan (Leinster), CJ Stander (Munster), Josh van der Flier (Leinster).