Italy are anxious to turn over a new leaf in the Six Nations after last year's wooden-spoon performance.
Italy know what it takes to beat Ireland on home soil having beaten them 22-15 in 2013.
"We are really impatient to start," Newcastle lock Josh Furno said.
"The Six Nations is the most important event in our season and we can't wait to get started."
Jacques Brunel's men are desperate to rediscover their winning touch and the 25-year-old Furno believes Italy can deliver right from the start.
"I believe we can do well against Ireland," Australia-born Furno said.
Italy will be without experienced lock Quintin Geldenhuys for the entire tournament.
With Geldenhuys out, Zebre lock Biagi has been included in the starting XV alongside Treviso flanker Francesco Minto who comes in for injured flanker Samuela Vunisa.
The two players are the only changes made by Brunel in his starting line-up with respect to the side that lost 22-5 to South Africa in Padua in Italy's last autumn Test in November.