Roberto Martinez (pictured) hasn't enjoyed the start to the season we would have hoped for at Everton whereas Southampton, up until recently, had exceeded most expectations after a big summer clear-out.
When they meet tomorrow, it is Everton who are expected to claim all three points at odds of 21/10 and inflict a sixth defeat in a row on the Saints in all competitions.
We have to wait until Monday's game between Stoke and Chelsea for the bet of the weekend.
With the busy Christmas period nearly upon us there will be many odds-on shots to mull over but Chelsea at 4/6 to beat Stoke looks one of the best you'll get.
Man United can make it seven wins on the trot against Aston Villa, while QPR can get a vital three points against fellow strugglers West Brom.