Ian Williams has confirmed Weird Al will go for glory in the totesport Cheltenham Gold Cup.
After undergoing surgery to correct a breathing problem, Williams is keen to let his exciting charge take his chance in the blue riband event.
"We've decided that Weird Al goes for the Gold Cup. He's got to step up his game a little," said Williams.
Weird Al is a best priced 40-1 for the Festival's feature contest on Friday.
Robert Thornton will replace Hadden Frost on Henrietta Knight's Somersby in the sportingbet.com Queen Mother Champion Chase at the Cheltenham Festival on Wednesday.
"Choc (Thornton) rode him twice last year. Hadden has done nothing wrong on Somersby but he lacks the experience of championship races," said Knight.
Voy Por Ustedes is a fascinating supplementary entry for the Ryanair Chase at Cheltenham on Thursday.
The Robert Ogden-owned 10-year-old is a dual Festival winner, having enjoyed previous success in the Arkle Trophy and the Champion Chase.
Poquelin is also among the 16 confirmations, while a seven-strong Irish entry includes Captain Cee Bee, Golden Silver, J'y Vole and Tranquil Sea.
Big Buck's and Grands Crus are the headline acts among 14 remaining horses in the Ladbrokes World Hurdle at Cheltenham on Thursday.
After winning the race for the second successive year last season, Big Buck's seemed set to emulate three-times scorer Inglis Drever.
But the emergence of David Pipe's Grands Crus, unbeaten in three starts, has sparked the race into life.
Bergo will have his attentions turned back to National Hunt racing following his fine effort in defeat at Meydan.
The eight-year-old showed huge improvement to finish second to Whispering Gallery in the Group Three DRC Gold Cup.
Brian Ellison will wait until Monday before deciding on Marsh Warbler's target at Cheltenham as the former Mark Johnston inmate could now run in Tuesday's Supreme Novices' Hurdle rather than the Triumph Hurdle.
Ellison said: "Obviously we'd rather go for the Triumph and keep him against his own age group but the ground is the issue.
"We are just worried that if we waited until Friday and the ground got fast, that would be dead against us."
David Sewell could have as many as three runners at the Festival.
The retired Cheltenham-based businessman has an increasingly large string at Alan King's stable, and could be represented by Oh Crick, Sir Harry Ormesher and Jetnova.