Pandorama has been ruled out for the entire season after failing to fully recover from an injury sustained in March's Cheltenham Gold Cup.
Last year's Lexus Chase winner finished seventh on unsuitably fast ground in the Prestbury Park blue riband and returned home sore.
Trainer Noel Meade had hoped his star chaser would be able to defend his Lexus crown at Leopardstown over Christmas, but he has been forced to write off the full campaign.
"We've decided to give him the year off," said Meade.
"He was very sore after Cheltenham and had a bit of heat in a leg.
"We've tried to take it slowly with him since he came back in but the heat has come back, and I thought I'm not going to take any chances with him and we'll give him the season off.
"You always worry when they get heat in a leg like that and we'll have to see what happens after he's had a break."
Kieren Fallon has been fined a total of £3,140 by the disciplinary panel of the British Horseracing Authority over his failure to arrive in time to take his first two rides at Chester on May 5.
The BHA looked into the circumstances surrounding Fallon's late arrival at the course to ride Fred Willetts and Forte Dei Marmi.
The six-time champion jockey was given the lion's share of the fine, £3,000, after being found guilty of deliberately misleading a BHA employee, William Nunneley, who was head of stewarding at the course that day.
He was handed the other £140 for not informing the clerk of the course, with an explanation, as soon as possible after he became aware he would be unable to ride the two horses in those races. The BHA will publish the full reasons for its decisions in due course.
Tony McCoy is hoping Binocular can kick start the new campaign in the best possible way in the Stanjames.com "Fighting Fifth" Hurdle at Newcastle on Saturday.
The seven-year-old, trained by Nicky Henderson, was among seven horses confirmed for the Gosforth Park showpiece at the five-day stage.
The 16-time champion jockey felt the 2010 Champion Hurdle hero, owned by his boss JP McManus, was never at his best last term even though he did win two races.
"He had a disappointing year and is not the easiest horse in the world to keep right," McCoy said.
"He's always had little problems and last season never went according to plan at any stage."
Paul Barber is keeping his fingers crossed that Denman can take a leaf out of old rival Kauto Star's book when he returns to action at Leopardstown next month.
The 11-year-old Kauto Star rolled back the years to defeat younger champion Long Run with an imperious performance in Saturday's Betfair Chase after many had written him off.
Stablemate Denman is the same age and in a similar boat, but he too has been pleasing trainer Paul Nicholls ahead of his intended comeback in the Lexus Chase.
"He's looking great at the moment and enjoying life," said Barber.