Bono sent U2 fans into a frenzy of speculation that the band are set to call it quits after he said they are "going away now".
The Dublin rockers recently wrapped up their Experience + Innocence tour with their final performance in Berlin on Tuesday.
Speaking to the crowd at the Mercedes-Benz Arena, Bono said: "We've been on the road for quite some time now - it's going on 40 years - and this last four years have been really something very special for us. We're going away now."
He then thanked the group's fans who "follow us all over the world".
The Twitter fan account @2gigs posted the transcript of Bono's speech, leading some fans to believe they are planning on splitting up after 40 years together.
However, the account later tweeted that there was speculation at the end of every one of U2's tours that "their break-up is imminent".
"Every tour I've covered, right back to Vertigo, every final gig is the same: mass panic that this is the last gig (well, OK, not on JT30 since this tour had already been announced)," they wrote.
"Ten bucks says I'll be covering another gig with you folks sometime down the track."
Another tweet read: "I will concede that this is the first time the mass panic has at least seemed plausible. But there'll be something for Boy at 40 or AB at 30, or a new record.
"U2 won't sit still and they won't break up, and they've got enough years ahead of them yet to fit in more gigs."
In a recent interview, Bono admitted he was not sure if there would be another world tour for the band after this one. "I don't know. I don't take anything for granted," he said.
The Dubliner said touring could be physically demanding and, without going into details, mentioned a "shock to the system" he had in late 2016.
"This tour is particularly demanding. Whether you have a face-off with your own mortality or somebody close to you does, you are going to get to a point in your life where you ask questions about where you're going," he said.
Earlier this year during the tour, Bono lost his voice at a concert in Berlin, but he was back doing his stuff three days later.
The group recently performed in Ireland, with four nights at the 3Arena.
The gigs, all of which sold-out, were well received.
On the first night at the venue, Bono introduced the group as "a band from the northside of Dublin".
Hollywood A-lister Woody Harrelson was at the band's first gig in the capital, while they had a star-studded affair for their wrap party after their final Irish concert.
The group were joined by stars including Shane MacGowan, Robbie and Claudine Keane, Ryan Tubridy, Laura Whitmore, Gavin James, Danny O'Donoghue and Glen Hansard.