Oscar-winner Natalie Portman has turned down a role in the upcoming Steve Jobs biopic.
According to insiders, the Black Swan actress was in line to play Jobs' daughter, Lisa Brennan-Jobs.
Irish actor Michael Fassbender (37) has already been cast as Jobs and Seth Rogen will play Steven Wozniak.
Danny Boyle is directing the film and Aaron Sorkin penned the script with some input from Walter Isaacson, who wrote the entrepreneur's official biography.
The biopic has had a troubled start, with Leonardo DiCaprio and Christian Bale both withdrawing from the main role and now Natalie leaving the film.
The decision of the 33-year-old star comes shortly after Sony Pictures pulled out of the planned biopic of Jobs - who tragically passed away from pancreatic cancer in 2011, aged 56 - and Universal picked up the project.
The movie will focus on three key moments from the CEO's life: the launch of the Mac, the takeover of computer company NeXT and the production of the iPod.
Production on the highly-anticipated movie is due to start in the spring but despite Portman pulling out, industry insiders told Variety magazine that they are still on track to start filming in the New Year.
It is understood that a number of other actresses are now in talks to take over the role of the Apple creator's daughter.
While he may not be working with Portman, Fassbender's career has been firmly on the rise in the last year and he has also recently started dating Swedish actress Alicia Vikander. The pair were spotted walking with their arms wrapped around each other in Sydney recently where they are filming The Light Between The Oceans.
The film tells the story of a lighthouse keeper and his wife who live off the coast of Western Australia and raise a baby they rescue from an adrift rowboat.
The new couple were also spotted surfing together on Bondi beach last week, but avoided any displays of affection at the busy tourist spot.