Activists are celebrating following a High Court decision extending protection to several more 1916 Rising-related buildings on and around Moore Street.
Judge Max Barrett ruled the buildings, in addition to four already declared a national monument, must be preserved because of their historical importance.
James Connolly Heron, a great-grandson of executed leader James Connolly said he was delighted at the decision.
"This is the culmination of a decade-long campaign where citizens of Dublin came together to protect and preserve the very birthplace of the republic," he said. "They stood together in principle for over a decade against great odds, almost the same odds as the volunteers in 1916 went out to meet."
He told the Herald that historians declared it the most important site in modern Irish history.
Dublin saw the destruction of its Wood Quay Viking heritage in the 1970s, which makes yesterday's court victory all the sweeter, said Mr Connolly Heron.
Heritage Minister Heather Humphreys said she and her officials "will consider this judgment in detail before making any decisions on further actions".
She regretted that "the public will not now be in a position to access 14 to 17 Moore Street during the centenary period as had been planned".
Judge Barrett ruled that various buildings and locations on and around Dublin's Moore Street are a 1916 Rising "battlefield site" comprising a national monument.
What happened to the men and women who fled the GPO when it was ablaze was "a matter worthy of unique commemoration", he said.
Some of the buildings were due for demolition as part of a major development for a museum and shopping centre.
Judge Bennett made orders against the minister, restraining unauthorised works at numbers 13 to 19 Moore Street, but said that once the minister decides how best to proceed, she may apply to vary those orders.