Spills of hazardous material, burning cars, loose animals and vehicles driving in the wrong direction were among more than 4,100 accidents, incidents and breakdowns on the country's busiest road since the start of January last year.
Twenty-one "major" incidents were recorded on the M50 ring road, according to figures released by Transport Infrastructure Ireland.
A total of 969 "high-priority" incidents were also reported over the past 21 months.
A log reveals there were two incidents involving spills of hazardous chemicals and 24 reports of vehicles on fire.
In seven cases, a car or truck was reported to be travelling in the wrong direction on the road, which has for most of its length a 100kmh limit.
There were 23 cases involving a live animal on the road and 11 instances where a dead animal was causing a hazard for motorists.
Two cases of serious anti-social behaviour were listed where there was a "moderate" risk to people travelling on the road.
In 188 cases logged, a car was reported abandoned or missing along the motorway while there were 1,538 cases of vehicles breaking down.
Collisions, from minor prangs to serious multi-vehicle crashes, numbered 901, while 210 cases of a cyclist or pedestrian on the road were also reported.
There were 15 cases of a "medical emergency" and eight incidents where there was a call from a roadside helpline but no caller on the other end.
There were also 34 incidents logged of spillages and 192 occasions when surface water was causing a hazard.
Of the 4,109 incidents logged between January last year and the end of last September, nearly a quarter were classified as "major" or "high priority".
There were 1,439 "moderate priority" incidents, 1,429 "low priority" incidents and 11 with no classification.
Sean O'Neill, of Transport Infrastructure Ireland, said: "It's a critical regional and national corridor. If there's an incident along the M50, even a minor one, and it's not dealt with in a timely manner, the impacts can be significant."