The Afternoon Show had been beset with a series of headaches since early last year. The first signs of trouble on the show emerged in March when Sheana Keane disappeared from her co-hosting slot.
Sheana (34) was missing for a number of weeks, but initially quelled rumours by issuing a statement saying she was out of work for "personal reasons".
Later, RTE representatives confirmed that she was suffering from a difficult bout of vertigo.
Those close to the duo insisted that the two were the best of friends and there was no row between the pair.
The show's Friday co-presenter and entertainment reporter Trevor Keegan stepped into the breach.
Ms Keane was a veteran on the Afternoon Show, having appeared in four of the show's five seasons.
RTE confirmed that she was not expected to make a comeback "until she is well enough to do so".
Gaelgoir Blathnaid (38) chose not to make any comment after Sheana left the airwaves and focused her attention on judging at the All Ireland Talent Show.
During the summer, rumours abounded as to the future of the show and a number of high-profile names mentioned.
Then, after the summer, in another dramatic turn of events, Blathnaid announced that she had been given medical advice to reduce her workload.
"It's with regret that I'm not returning to The Afternoon Show," Blathnaid said. "I was there for five seasons and it was a great show to work on, but my medical advice is very clear -- a two-hour live show every day is just too much."
A rake of presenters, including Sile Seoige, then took a rotating slot in place of Blathnaid, for an extended period as Sheana returned from her sick leave.
Maura Derrane (39) was brought in for a number of shows and has been in situ as co-presenter since October 2009. She was confirmed as official presenter just before Christmas.