RTE's Operation Transformation wants to focus on people with diabetes and women having trouble conceiving because of their weight.
The makers of the popular TV programme want to tackle the health problems which obesity can lead to in the next series.
Production company VIPMG has published an ad calling for a Type 2 Diabetes patient to be a leader on the show. And they are also appealing to women who have been turned away from in vitro fertilisation (IVF) treatment because their body mass index (BMI) is over 30.
"For the next series, Operation Transformation intends to follow women who are taking steps to reduce their BMI, before they begin their IVF," the production company said in one ad.
Another ad said: "We are looking for people whose lives have been affected as a result of developing T2D. It doesn't matter what age you are, or where you live, Operation Transformation would love to hear from you."
A spokesperson for VIPMG told the Herald: "It'll air in January, and we're just putting the call out next week and putting ideas together."
Dr Anna Clarke, health promotions officer at the Diabetes Federation of Ireland, said the issue desperately needs to be highlighted.
"We currently have 150,000 people with Type 2 Diabetes in Ireland and a recent VHI survey said there are 146,000 with pre-diabetes in Ireland and if they don't address their lifestyle issues they're likely to be diagnosed in the next five years," she said.
"There's already been an explosion and it's likely to affect the health service. At least 15pc of people currently occupying acute hospital beds are in there because of diabetes."