Lynn Redgrave, a member of the Redgrave acting dynasty, has died aged 67 following a long battle with breast cancer.
The actress, the younger sister of Vanessa Redgrave, was at home in Connecticut on Sunday night with her three children Ben, Pema and Annabel around her.
They issued a joint statement through her publicist Rick Miramontez which read: "Our beloved mother Lynn Rachel passed away peacefully after a seven year journey with breast cancer.
"She lived, loved and worked harder than ever before. The endless memories she created as a mother, grandmother, writer, actor and friend will sustain us for the rest of our lives. Our entire family asks for privacy through this difficult time."
Redgrave's career spanned four decades, and she was nominated for two Oscars, three Tony awards, two Emmys and a Grammy.
She became a 1960s sensation as the freethinking title character of "Georgy Girl".
The youngest child of Sir Michael Redgrave and Rachel Kempson, Redgrave did not achieve the same fame as her sibling Vanessa Redgrave, 73, but was a well-known figure on Broadway.
She received Tony nominations for her theatre performances in "Mrs. Warren's Profession," "Shakespeare for My Father" and "The Constant Wife." Her Oscar nominations were for Georgy Girl and Gods And Monsters.
Her death is the latest in a series of tragedies to strike the Redgrave family.
Last year Redgrave's niece Natasha Richardson, 45, died from head injuries sustained in a skiing accident in Canada and last month she attended the funeral of her older brother, Corin Redgrave, 70.
Redgrave divorced her husband John Clark after 32 years of marriage in 2000 after it was disclosed in a tabloid interview that he had fathered a child with their son's wife, Nicolette Hannah.
Miss Hannah had been Clark's assistant before marrying Miss Redgrave's eldest child Ben, an airline pilot, and giving birth to a boy, Zack.
Redgrave was first treated for breast cancer in 2003 and co-wrote a book in 2004 with her youngest daughter Annabel, a photographer, called Journal: A Mother and Daughter's Recovery from Breast Cancer.
She recorded how the treatment "set me free".
"Vanessa was the one expected to be the great actress," she told an interviewer in 1999. "It was always, 'Corin's the brain, Vanessa the shining star, oh, and then there's Lynn'.
"All the films I've been in — and I haven't been in that many attention-getting films — no one expected anything of, least of all me."
Redgrave has been open about her personal life. In plays and in interviews, Lynn Redgrave confided about her family, her marriage and her health. One of her four plays, Shakespeare for My Father, was written in a bid to better understand her father after he died in 1985.
She also acknowledged that she suffered from bulimia and served as a spokeswoman for Weight Watchers.
Her most recent film performances included a cameo in Confessions of a Shopaholic last year and as well voicing an animated film called My Dog Tulip alongside Christopher Plummer and Isabella Rossellini.
Director Michael Winner, who cast Redgrave in one of her first films, paid tribute to the actress.
He said: "This is terrible news, I've known her for more than 50 years. She was a phenomenal actress, she could do comedy, tragedy - anything really - with absolute ease.
"I cast her in her first film as an extra in Shoot To Kill in 1960. Even then you could see she had a bubbly quality.
"She was a wonderful person and a brave woman involved in many causes. She wasn't facile - she didn't only care about fame."